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目的：探讨 Ｅ Ｇ Ｆ Ｒ、ｎｍ２３ Ｈ１ 及ｐ５３ 蛋白在甲状腺乳头状腺癌中的表达及其与淋巴结转移的关系。方法：应用免疫组化 Ａ Ｂ Ｃ 法检测３６ 例有颈淋巴结转移的甲状腺乳头状腺癌的原发灶与转移灶和４０ 例无转移的甲状腺乳头状腺癌中 Ｅ Ｇ Ｆ Ｒ、ｎｍ２３ Ｈ１ 及ｐ５３ 蛋白的表达。结果：７６ 例甲状腺乳头状腺癌的 Ｅ Ｇ Ｆ Ｒ、ｎｍ２３ Ｈ１ 及ｐ５３ 蛋白的阳性表达率分别为５５３ ％ 、６０５ ％ 和１１８ ％ ；但有转移的甲状腺乳头状腺癌的 Ｅ Ｇ Ｆ Ｒ 阳性表达率高于无转移者（ Ｐ＜ ００５） ，且转移灶的 Ｅ Ｇ Ｆ Ｒ 阳性率明显高于其原发灶（ Ｐ＜ ００５） ；有转移的甲状腺乳头状腺癌的ｎ ｍ２３ Ｈ１ 阳性率低于无转移癌者（ Ｐ＜ ００１） ；甲状腺乳头状腺癌中 Ｅ Ｇ Ｆ Ｒ 的阳性表达与ｎ ｍ２３ Ｈ１ 的表达有负相关（ Ｐ＜ ００１） 。结论：甲状腺乳头状腺癌 Ｅ Ｇ Ｆ Ｒ 的过表达，ｎｍ２３ Ｈ１ 的低表达，二者表达的失平衡是其易于淋巴结转移的原因之一， Ｅ Ｇ Ｆ Ｒ，ｎｍ２３ Ｈ１ 联用可作为甲状腺乳头状腺癌淋巴结转移的评价指标。
Objective: To investigate the expression of EGFR, nm23H1 and p53 proteins in papillary thyroid carcinoma and its relationship with lymph node metastasis. METHODS: Immunohistochemical A B C method was used to detect primary tumors and metastases of 36 cases of thyroid papillary adenocarcinoma with cervical lymph node metastases and 40 cases of non-metastasis thyroid papillary adenocarcinomas. E G F R, nm23 H1 And p53 protein expression. RESULTS: The positive expression rates of EGFRF, nm23 H1, and p53 protein in 76 cases of papillary thyroid carcinoma were 55. 3%, 60.5%, and 11.8%, respectively; however, there were metastatic thyroid papillary glands. The positive expression rate of EGFR was higher in cancer than in non-metastasis (P < 0. 05), and the positive rate of EGFRR in metastasis was significantly higher than that in primary tumor (P <0. 05); The positive rate of n m23 H1 in thyroid papillary adenocarcinoma was lower than that in non-metastasis (P<001). The positive expression of E G F R in thyroid papillary adenocarcinoma was negatively correlated with the expression of n m23H1 ( P< 001). Conclusion: The over-expression of EGFR in thyroid papillary adenocarcinoma, and the low expression of nm23H1, is one of the reasons for its easy lymph node metastasis. E G F R, nm23H1 can be used as a combination. Thyroid papillary adenocarcinoma lymph node metastasis evaluation indicators.