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目的观察肝细胞癌(HCC)患者经导管动脉化疗栓塞(TACE)治疗前后磁共振灌注加权成像(MRPWI)灌注值改变。方法对22例HCC患者在TACE术前和术后3～10天分别进行MRPWI,得出术前及术后平均强化时间(MTE)、负增强积分(NEI)、病灶达峰值时间(TTP)、最大信号下降斜率(MSD),比较TACE术前与术后上述各指标的差异。结果HCC瘤区时间信号曲线(TIC)TACE术前呈快速下降,TACE术后趋向平缓;MTE与TTP值术后较术前降低,NEI值术后较术前升高,差异均有统计学意义(P<0.05);MSD值术后较术前降低,但差异无统计学意义(P>0.05)。结论MRPWI能够敏感地观察到HCCTACE术前后的血流变化,可用于评价TACE疗效。
Objective To observe the perfusion changes of MRPWI in patients with hepatocellular carcinoma (HCC) before and after transcatheter arterial chemoembolization (TACE). Methods Twenty-two patients with HCC underwent MRPWI before TACE and 3 to 10 days after operation. The mean preoperative and postoperative mean enhancement time (MTE), NEI, TTP, Maximum signal descent slope (MSD), comparing TACE before and after the above indicators of the difference. Results The TIC of TCC decreased rapidly before TACE, and tended to be gentle after TACE. The values of MTE and TTP were lower than those before operation and the NEI values were significantly higher after operation than those before operation (P <0.05). MSD decreased after operation, but the difference was not statistically significant (P> 0.05). Conclusion MRPWI can sensitively observe the changes of blood flow before and after HCCTACE and can be used to evaluate the efficacy of TACE.