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急性原因不明的髓样化生(AAMM)是一种性质尚不明确的不同于慢性骨髓纤维化的独立的疾病。本文报道一例37岁女性患者,主要临床特点为病程凶险、中度脾肿大、进行性面色苍白、皮肤粘膜经常出血、白细胞和血小板持续减少、网织红细胞明显降低、髓外造血显著、周围血中不典型的原粒细胞百分比较高(10～31%)、多次不同部位的骨髓穿刺均为干抽、骨髓活检提示急性广泛性骨髓纤维化、血片氯醋酸ASD萘酚脂酶强阳性。细胞遗传学检查发现周围血中有三体-8异常克隆存在。根据上述表现,本例应诊断为AAMM。患者因进行性贫血和出皿,反
Acute myeloid metaplasia (AAMM) is an undifferentiated and independent disease that is different from chronic myelofibrosis. This article reports a case of 37-year-old female patients, the main clinical features of the course of dangerous dangerous, moderate splenomegaly, progressive pale, frequent mucocutaneous bleeding, leukocytes and platelets continued to reduce reticulocyte was significantly reduced extramedullary hematopoietic peripheral blood In the typical high percentage of myeloblasts (10 ~ 31%), many different parts of the bone marrow puncture are dry pumping, bone marrow biopsy prompted acute extensive bone marrow fibrosis, blood acetate acetate ASD naphthol strong positive . Cytogenetic examination revealed abnormal trisomy 8 in the peripheral blood. Based on the above performance, this case should be diagnosed as AAMM. Patients due to progressive anemia and a dish, anti