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动脉粥样硬化是一个复杂的全身性的炎症过程。病变部位形成粥样斑块,最终斑块破裂引发血栓形成是导致急性冠脉综合征发生的主要原因。他汀类在动脉粥样硬化的治疗中发挥着越来越重要的作用。除了降脂作用,他汀类更具有潜在的多效性,包括提高一氧化氮生物利用度、修复受损内皮、抗炎、抗氧化、促新生血管形成、稳定动脉粥样硬化斑块、动员内皮祖细胞等。现就当前他汀类多效性的主要研究进展作一综述。
Atherosclerosis is a complex, systemic inflammatory process. Lesions form atherosclerotic plaque, the final cause of plaque rupture is the leading cause of acute coronary syndrome. Statins play an increasingly important role in the treatment of atherosclerosis. In addition to lipid-lowering effects, statins are more potentially pleiotropic, including increasing nitric oxide bioavailability, repairing damaged endothelium, anti-inflammatory, antioxidant, angiogenic, stabilizing atherosclerotic plaques, mobilizing endothelium Progenitor cells. Now on the current statin pleiotropic major research progress is reviewed.