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目的 :评价组织多肽特异性抗原 (TPS)、CYFRA2 1- 1和癌胚抗原 (CEA)在各种病理类型肺癌中诊断的应用价值 ,通过联检观察它们在肺癌诊断中的敏感性和有效性。方法 :收集血清标本 12 7例 ,其中肺鳞癌 2 2例 ,腺癌 19例 ,小细胞肺癌 16例 ,不能分型肺癌组 13例 ,肺部良性疾病组 2 7例和正常对照 30例。采用酶联免疫吸附试验进行检测。结果 :TPS、CYFRA2 1- 1和CEA在肺癌各病理类型组的血清水平与正常对照组有差异 (P <0. 0 5 ) ,TPS和CEA在肺癌各病理类型组的血清水平高于良性病变组 (P <0 . 0 5 ) ,CYFRA2 1- 1在肺癌各病理类型组的血清含量与肺癌良性疾病组无差异 (P >0 . 0 5 )。TPS在肺癌组的灵敏度最高 ,为 85. 7% ,在肺部良性病变组的灵敏度为 2 9. 6 % ,TPS在肺癌各病理类型组的灵敏度无差异(P >0 .0 5 ) ,其特异性为 78 9%。CYFRA2 1- 1和CEA在肺癌的灵敏度分别为 2 7 .1%和 2 2 8% ,CYFRA2 1- 1在肺鳞癌中灵敏度最高 36 . 4 % ,CEA在肺腺癌中最高为 31 .6 %。TPS、NSE ,CYFRA2 1- 1和CEA三项联检 ,可明显提高肺癌诊断的灵敏度 ,但同时特异性有所下降。结论 :TPS在肺癌诊断上灵敏度较高 ,但特异性较差 ,不宜单独用于肺癌诊断。CYFRA2 1- 1和CEA在肺癌诊断上灵敏度较低 ,但特异性强 ,在肺癌诊?
Objective: To evaluate the value of TPS, CYFRA2 1- 1 and carcinoembryonic antigen (CEA) in the diagnosis of various pathological types of lung cancer. Their sensitivity and effectiveness in the diagnosis of lung cancer were evaluated by joint examination. Methods: A total of 127 serum samples were collected, including 22 lung squamous cell carcinoma, 19 adenocarcinoma, 16 small cell lung cancer, 13 lung cancer without classification, 27 pulmonary benign disease and 30 normal controls. Enzyme-linked immunosorbent assay was used for detection. Results: Serum levels of TPS, CYFRA2 1- 1 and CEA were significantly different from those of normal controls (P 0.05). The serum levels of TPS and CEA in all pathological types of lung cancer were higher than those in benign lesions (P <0.05). The serum levels of CYFRA2 1- 1 in all pathological types of lung cancer were not significantly different from those in benign lung cancer (P> 0.05). The sensitivity of TPS was the highest in lung cancer group (85.7%). The sensitivity of TPS in lung benign lesion group was 26.6%. The sensitivity of TPS in lung cancer group was no significant difference (P> 0.05) Specificity was 78 9%. The sensitivity of CYFRA2 1- 1 and CEA in lung cancer were respectively 27.1% and 22.8%. CYFRA2 1- 1 had the highest sensitivity of 36.4% in lung squamous cell carcinoma and the highest CEA in lung adenocarcinoma of 31.6 %. TPS, NSE, CYFRA2 1 - 1 and CEA three joint inspection, can significantly improve the sensitivity of lung cancer diagnosis, but at the same time decreased specificity. Conclusion: TPS is more sensitive in the diagnosis of lung cancer, but its specificity is poor. It should not be used alone for the diagnosis of lung cancer. CYFRA2 1- 1 and CEA in the diagnosis of lung cancer lower sensitivity, but the specificity of strong, diagnosis of lung cancer?