重金属是当今环境污染物中关注度最高的毒物类别之一,其可对人体多个系统和器官造成严重的损伤.氧化损伤是重金属中毒的发生机制之一.核转录相关因子-2(nuclear factor-erythroid 2-related factor2,Nrf2)作为一类具有抗氧化功能的转录因子,通过识别并结合抗氧化反应元件(antioxidant response element,ARE),进一步启动多种抗氧化酶类的转录,清除多余的自由基,在重金属中毒的防治中起到重要作用.该文对Nrf2信号通路结构与作用及其在重金属锰、汞、镉、铅中毒发生过程中的调控作用进行综述,为重金属中毒防治提供新思路.“,”Recently,heavy metals have been one of the most concerned toxitants of the environmental pollution,which do harm to apparatus and tissue of individual.Oxidative damage is one of the mechanisms of heavy metal poisoning.Nuclear factorerythroid 2-related factor2 (Nrf2) is a kind of transcription factor with the function of antioxidation.It can promote the transcription of a variety of antioxidant enzymes and remove excess free radicals by recognizing and binding to the antioxidant response element(ARE),which plays an important role in the prevention and treatment of heavy metal toxicity.This review will focus on the structure and function of Nrf2 signaling pathway,as well as its regulatory effect on the process of manganese,mercury,cadmium and lead poisoning,in order to provide a new method to prevent heavy metal toxication.