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异丙肌苷(Isoprinosine)是肌苷与2-羟丙二甲基铵4-乙酰氨基苯甲酸按1:3的比例组成的分子复合物。经体内外实验显示,该药能抑制多种DNA及RNA病毒的复制,并具有增强T-淋巴细胞及巨噬细胞功能的免疫调节效果。作者对其治疗慢性活动性乙型肝炎(CAH-B)的效果进行了研究。作者选择了治疗前连续观察HBsAg、HBeAg及HBV DNAP呈阳性至少1年的39例CAH-B病例。21例为异丙肌苷治疗组,18例作为对照。两组病例的年龄、性别、
Isoprinosine is a molecular complex of inosine and 2-hydroxypropylammonium 4-acetamidobenzoate in a 1: 3 ratio. In vitro and in vivo experiments show that the drug can inhibit the replication of a variety of DNA and RNA viruses, and has the effect of enhancing the immune regulation of T-lymphocytes and macrophages. The authors studied the effect of treating chronic active hepatitis B (CAH-B). The authors selected 39 consecutive cases of CAH-B who had HBsAg, HBeAg and HBV DNA positive for at least 1 year before treatment. 21 cases were treated with isoposide, and 18 cases were used as control. Two groups of patients age, gender,