论文部分内容阅读
目的:观察中西医结合治疗胃食管反流病的临床疗效。方法:将本院普内科收治的90例胃食管反流病患者随机分为对照组和观察组各45例,对照组予单纯西药治疗(奥美拉唑肠溶胶囊加枸橼酸莫沙必利片);观察组则在对照组治疗基础上予柴胡泻心汤口服,并配合胃复安穴位注射进行治疗。总疗程均为3月。疗程前后均进行中医证候积分及RDQ量表积分评估,行胃镜检查及24 h食管p H值监测,随访患者治疗期间不良反应发生情况。结果:2组患者中医证候积分、RDQ量表积分及24 h食管p H值监测p H值<4的时间均较治疗前有下降,且组间比较,差异均有统计学意义(P<0.01),观察组优于对照组;观察组总有效率优于对照组,差异有统计学意义(P<0.01);2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:中西医结合治疗胃食管反流病能有效改善患者临床症状,减少胃酸分泌,改善食管黏膜病变情况,临床效果良好且不良反应少,优于单纯西药治疗。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of gastroesophageal reflux disease. Methods: 90 cases of gastroesophageal reflux disease admitted to our hospital were randomly divided into control group and observation group (n = 45). The control group was treated with western medicine alone (omeprazole enteric-coated capsules plus mosapride citrate Lee tablets); the observation group was treated with Chaizhu Xiexin Tang on the basis of the control group, and treated with the combination of Atrazine and Acupoint Injection. The total course of treatment is March. Before and after treatment, TCM syndrome score and RDQ scale score were evaluated. Endoscopy and 24-hour esophageal p H value monitoring were followed up, and the incidence of adverse reactions during follow-up was observed. Results: The time points of TCM syndrome score, RDQ scale score and 24 h esophageal p H value monitoring p H value <4 were lower than those before treatment in both groups, and there were significant differences between the two groups (P < 0.01). The observation group was better than the control group. The total effective rate in the observation group was better than that in the control group (P <0.01). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion: The treatment of gastroesophageal reflux disease by traditional Chinese and western medicine can effectively improve the clinical symptoms, reduce the gastric acid secretion and improve the esophageal mucosal lesions. The clinical effect is good and the adverse reaction is less, which is superior to the western medicine alone.