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目的研究妊娠期高血压疾病大鼠甲状腺激素水平及甲状腺组织的超微病理改变,探讨妊娠期高血压疾病甲状腺组织结构损伤是否与其激素水平变化相一致。方法采用亚硝基左旋精氨酸甲酯(L-NAME)建立妊娠期高血压疾病模型大鼠,发光免疫法测定正常妊娠组、妊娠期高血压疾病模型组(PIH组)大鼠血清中FT3、FT4及TSH的浓度变化,透射电镜下观察甲状腺组织的结构变化。结果 PIH组FT3、FT4水平较正常妊娠组呈下降趋势,TSH水平显著升高(P<0.05);电镜下观察PIH组大鼠甲状腺滤泡上皮细胞损伤明显,主要显示甲状腺功能低下。结论甲状腺亦是妊娠期高血压疾病慢性攻击的靶器官,妊娠期高血压疾病存在甲状腺组织形态学的改变,与血清中激素浓度变化意义基本相同。
Objective To study thyroid hormone levels and thyroid tissue ultrastructural changes in hypertensive disorder complicating pregnancy and to explore whether structural damage of thyroid tissue in hypertensive disorders of pregnancy is consistent with changes of hormone levels. Methods The model of hypertensive disorder complicating pregnancy was established by nitroso-L-arginine methyl ester (L-NAME). The level of FT3 in serum of normal pregnancy group and PIH group , FT4 and TSH concentration changes, the transmission electron microscopy of thyroid tissue structure changes. Results The levels of FT3 and FT4 in PIH group showed a decreasing trend compared with those in normal pregnancy group, and the TSH level was significantly increased in PIH group (P <0.05). The thyroid follicular epithelial cells were obviously damaged in PIH group and mainly showed hypothyroidism. Conclusions The thyroid gland is also the target organ of chronic attack of hypertensive disorders of pregnancy. The histopathological changes of thyroid tissue in hypertensive disorder complicating pregnancy have the same meaning as the change of hormone concentration in serum.