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青光眼滤过性手术的目的在于形成结膜下房水流出眼外的瘘道,同时形成滤过泡(Filtering bleb)达到眼压降低。而滤过泡的瘢痕增生常导致滤道闭塞、滤过功能丧失。自Gressel 等1984年提出结膜下注射氟尿嘧啶(5—FU)作为青光眼滤过性手术的辅助治疗以来,许多人相继应用于临床,其疗效令人瞩目。且已成为青光眼研究40年的进展之一。本文对近年5—FU 应用于青光眼滤过性手术的机理、临床疗效、使用方法及其并发症综述如下。(一)青光眼滤过性手术失败的主要因素青光眼滤过性手术及其改良术式不胜枚举,但手术失败者屡见不鲜。中谷一报道小梁切除术后经5年观察的223眼中,眼压上
The purpose of glaucoma filtration surgery is to form a fistula of aqueous humor that flows out of the eye through the conjunctiva, and to reduce the intraocular pressure by forming a Filtering bleb. The hyperplasia of bleb scar filtration often lead to occlusion, filtration loss. Since Gressel et al. (1984) proposed subconjunctival injection of 5-fluorouracil (5-FU) as an adjuvant therapy for glaucoma filtering surgery, many have been used clinically and have received impressive results. It has become one of the 40 years of research in glaucoma. In this paper, 5-FU in recent years, the mechanism of glaucoma filtration surgery, clinical efficacy, methods of use and its complications are summarized below. (A) the main factors of glaucoma filtration surgery failure Glaucoma filtration surgery and its improved surgical procedures are numerous, but the loser of surgery is not uncommon. Nakatani reported that in 223 eyes of 5 years after trabeculectomy, IOP was reported