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目的探讨血管紧张素原基因(AGT)多态性与慢性心力衰竭(CHF)发病的关系。方法应用聚合酶链反应-限制性片段长度多态性技术检测2004年4月至2005年12月珠海市3家医院的111例CHF患者和110名健康对照者的AGT基因M235T多态性并进行统计学比较。结果共检测出3种AGT基因型,分别为MM型、MT型和TT型。CHF患者TT基因型频率高于对照组,在老年病例与对照组间,差异具有统计学意义(P=0.042)。与非TT型者相比,老年TT型者发生CHF的相对风险率为3.367。结论AGT基因M235T多态性与CHF的发生相关,TT基因型可能是该地区老年人群CHF发病的遗传危险因素。
Objective To investigate the relationship between angiotensinogen gene (AGT) polymorphism and the pathogenesis of chronic heart failure (CHF). Methods The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect AGT gene M235T polymorphism in 111 CHF patients and 110 healthy controls from 3 hospitals in Zhuhai from April 2004 to December 2005. Statistical comparison. Results Three AGT genotypes were detected, which were MM, MT and TT, respectively. The frequency of TT genotype in CHF patients was higher than that in control group, and the difference was statistically significant between elderly patients and control group (P = 0.042). Compared with non-TT type, the relative risk of CHF in elderly TT type was 3.367. Conclusion The M235T polymorphism of AGT gene is associated with the development of CHF. The TT genotype may be the genetic risk factor of CHF in the elderly in this area.