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乙醛脱氢酶1(aldehyde dehydrogenase 1,ALDH1)蛋白属于乙醛脱氢酶家族中的一员,其表达与乳腺癌的发生、发展、预后和转移密切相关,且在乳腺癌干细胞表面高表达。本文就近年来有关ALDH1蛋白与乳腺癌关系的研究进展作一综述,包括ALDH1蛋白与乳腺癌干细胞、乳腺癌基因亚型、乳腺癌循环肿瘤细胞之间的关系及其对乳腺癌耐药、预后和转移的影响等方面。
Aldehyde dehydrogenase 1 (ALDH1) belongs to a member of acetaldehyde dehydrogenase family and its expression is closely related to the occurrence, development, prognosis and metastasis of breast cancer, and is highly expressed on the surface of breast cancer stem cells . This review summarizes recent advances in the relationship between ALDH1 protein and breast cancer, including the relationship between ALDH1 protein and breast cancer stem cells, breast cancer gene subtypes, circulating tumor cells in breast cancer and their relationship with drug resistance, prognosis and breast cancer The impact of transfer and so on.