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益生菌是活的非致病性细菌,具有改善微生态环境、维持人类健康状态的作用。“肠-肝轴”提示肠道微生物和肝胆之间有着复杂的关系。肠腔内微生物种类和数量的改变,可以通过生成氨和内毒素等一系列机制损害肝功能。一些研究证实了益生菌对预防和治疗儿童肝胆疾病(如胆汁淤积性肝病、非乙醇性脂肪肝、肝硬化和肝移植等)具有积极作用。益生菌作为一种安全、相对价廉、非侵入性的治疗策略,可以改善不同类型肝胆疾病的病理生理进程,减轻症状,且未见明显副反应,具有良好的应用前景。
Probiotics are living, non-pathogenic bacteria that have the potential to improve the micro-ecological environment and maintain human health. “Intestinal - hepatic axis” suggests a complex relationship between gut microbes and hepatobiliary. Intestinal cavity microbial species and quantity changes, can produce a series of mechanisms such as ammonia and endotoxin damage liver function. Some studies confirm that probiotics have a positive effect on the prevention and treatment of childhood hepatobiliary diseases such as cholestatic liver disease, non-alcoholic fatty liver disease, liver cirrhosis and liver transplantation. As a safe, relatively inexpensive and noninvasive treatment strategy, probiotics can improve the pathophysiological process of different types of hepatobiliary diseases, relieve symptoms and have no obvious side effects, which has a good prospect of application.