目的探讨微生态制剂对胃肠粘膜屏障的保护及对胃肠道菌群紊乱的治疗作用。方法150例患者分为四组(IBS组、抗生素相关性腹泻组、慢性腹泻组、肠术后组),每组患者再随机分为治疗组与对照组,两组患者各占一半。治疗组主要给予培菲康治疗,而对照组则给予其他相关治疗。所有患者均治疗2周,观察其临床疗效、便常规、便培养及肠道菌群紊乱改善情况。结果培菲康治疗组临床症状改善优于对照组(P<005),便常规的改善与肠道菌群紊乱的纠正亦优于对照组(P<005)。结论微生态制剂——培菲康可以明显改善因肠道菌群失调所致的急、慢性腹泻症状,纠正肠道菌群紊乱、维持肠道微生态平衡,从而保护、强固胃肠粘膜屏障。 Objective To investigate the protective effect of probiotics on the gastrointestinal mucosal barrier and the therapeutic effects on the gastrointestinal flora. Methods 150 patients were divided into four groups (IBS group, antibiotic-associated diarrhea group, chronic diarrhea group, intestinal group). Each group was divided into treatment group and control group randomly. The treatment group was given Pefikan treatment, while the control group was given other related treatment. All patients were treated for 2 weeks to observe the clinical efficacy, routine, then culture and intestinal flora to improve the situation. Results The improvement of clinical symptoms in Pefiikang treatment group was better than that in control group (P <005). The routine improvement and the correction of intestinal flora were also better than those in control group (P <005). Conclusion The probiotics - Pefikang can significantly improve the symptoms of acute and chronic diarrhea caused by the imbalance of intestinal flora, correct the disturbance of intestinal flora and maintain the intestinal microflora, so as to protect and strengthen the barrier of gastrointestinal mucosa.