论文部分内容阅读
目的 探讨小儿血清苗勒氏抑制物质 (MullerianInhibitingSubstance ,MIS)水平变化与小儿泌尿生殖器畸形的关系。方法 通过测定我院非泌尿生殖器疾病的 2～ 14岁男、女病人 ,隐睾病人血清MIS、睾酮 (Testosterone ,T)值了解⑴男、女体内MIS值的区别、变化规律 ;⑵MIS和T值的关系 ;⑶隐睾病人血清MIS值与非泌尿生殖器疾病病人血清MIS值的变化。结果 ⑴男性非泌尿系统疾病病人血清MIS值 1岁后呈逐渐下降曲线 ,均值从 ( 797 0 3± 2 46 12 )pmol/L至 ( 81 74± 3 8 40 )pmol/L有统计学意义 (P <0 0 1)。⑵睾酮在青春发育期前很低 ,至青春发育期开始升高 (P <0 0 1)。并且用S -N -K法组间比较发现从 13岁起T值有明显的上升 (P <0 0 5 )。⑶非泌尿系统男性病人血清睾酮和其MIS变化呈负相关 ,r =-0 . 3 14 ,P <0 0 5。⑷ 1～ 14岁非泌尿系统女性病人血清MIS值最高 5 2 87pmol/l ,最低为 0pmol/L ,平均 16 3 8pmol/L。各年龄段之间无明显差异 ( P >0 0 5 )。但性别对于MIS值有非常显著的影响 (排除年龄影响因素 ) (P <0 0 1)。⑸隐睾病人的MIS值与同龄儿相比较 ,1～ 11岁无明显差别 (P >0 0 5 ) ,12～ 14岁有显著性差异 (P <0 0 5 )。结论 MIS由男性睾丸塞托利细胞及女性卵巢颗粒细胞分泌 ,T由睾丸
Objective To investigate the relationship between the level of Mullerian Inhibition Substance (MIS) and pediatric genitourinary malformations in children. Methods The serum MIS and testosterone (T) values of male and female patients with cryptorchidism from 2 to 14 years old without genitourinary diseases in our hospital were investigated. The differences and changes of MIS values in male and female were analyzed. (2) The values of MIS and T Of the relationship; ⑶ cryptorchid patients serum MIS value and non-genitourinary diseases patients with changes in serum MIS value. Results (1) The serum MIS value of male patients with non-urological diseases showed a gradual descending curve after 1 year of age, with mean values from 797 034 +/- 246 12 pmol / L to 81 74 +/- 3840 pmol / L, P <0 0 1). (2) Testosterone was low before puberty and began to increase during puberty (P <0.01). And by S-N-K method group comparison found that T value from 13 years old had a significant increase (P <0 05). ⑶ Non-urinary male patients with serum testosterone and its MIS changes was negatively correlated, r = -0.314, P <0 05. ⑷ non-urinary 1 to 14-year-old female patients with serum MIS value of the highest 5 2 87 pmol / l, the lowest 0 pmol / L, an average of 16 3 8 pmol / L. There was no significant difference among all age groups (P> 0.05). However, gender had a very significant effect on MIS (excluding age-related factors) (P <0.01). (5) The cryptorchidism patients had no significant difference between the ages of 1 to 11 years (P 0 05) and the age between 12 and 14 years (P 0 05). Conclusion MIS is secreted by male testes sertoli cells and female ovarian granulosa cells, and T is composed of testis