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联合化疗明显地改善了何杰金氏患者的预后,年轻患者的存活数增加了,肿瘤虽然治愈,但也产生了长期化疗副作用的危害。作者研究15名男孩,2名女性儿童时期的何杰金氏病,应用MOPP(盐酸氮芥、长春新硷、甲基苄肼和强的松龙)联合化疗时,对性腺机能的影响。结果:8名男孩在青春期前接受化疗,其中5人青春期发育正常,另3人仍停留在9.8、10和11.8岁的年龄水平;7名男孩在青春期接受化疗,其中4人完全性成熟。化疗结束后,与青春期发育相对比,5例青春晚期或4例成年期患者现出小睾丸,只有1例发生轻度女性乳房。
Combined chemotherapy significantly improved the prognosis of Hodgkin’s patients, young patients increased the number of survival, although the tumor was cured, but also produced long-term adverse effects of chemotherapy. The authors studied Hodgkin’s disease in 15 boys and 2 female children and on gonadal function when combined with MOPP (mechlorethamine, vincristine, procarbazine, and prednisolone) in combination with chemotherapy. Results: Eight boys received chemotherapy before puberty. Five of them had normal puberty and the remaining three were at the age of 9.8, 10 and 11.8 years. Seven boys received chemotherapy during puberty and four of them were fully mature. After chemotherapy, adolescent development compared with 5 cases of late adulthood or 4 cases of adult patients showed small testicles, only 1 case of mild female breasts.