子宫内不利的生长环境可能使孩子在成年后更易于发生心血管疾病,但其潜在的机制尚不明确。在先兆子痫期间,病变的胎盘释放血管毒性因子到母体循环中。研究者推测这些因子通过胎盘屏障,并在孩子的循环中造成某种损害及缺陷,从而在孩子出生后易于产生病理反应。生活于高海拔环境所造成的组织缺氧有助于检测出上述缺陷。方法和结果:研究对象为先兆子痫母亲的孩子48例和正常妊娠母亲的孩子90例,这些孩 Uterine unfavorable growth environment may make children more susceptible to cardiovascular disease in adulthood, but its underlying mechanism is not yet clear. During pre-eclampsia, diseased placentas release vascular toxic factors into the maternal circulation. Researchers speculate that these factors pass through the placental barrier and cause some damage and defects in the child’s circulation, making them prone to pathological reactions after they are born. Tissue hypoxia caused by living in high altitude environment can help to detect the above defects. Methods and Results: Forty-eight children with pre-eclampsia mothers and 90 children with normal gestational mothers were enrolled. These children