有机磷农药广泛应用于农业生产和居住环境。由于发现有机磷农药暴露与胎儿神经管畸形、内脏畸形等出生缺陷有关,故其生殖毒性及其机制的研究成为近年来环境医学领域关注的热点。本文综述了有机磷农药对雌性生殖系统的毒性作用、对性周期和性行为的影响以及对生殖结局的毒性作用,并探讨其产生生殖毒性的可能机制。 Organophosphorus pesticides are widely used in agricultural production and living environment. The discovery of organophosphorus pesticide exposure and fetal neural tube defects, visceral malformations and other birth defects, so its reproductive toxicity and its mechanism of research has become the focus of environmental medicine in recent years, the focus of attention. This article reviews the toxic effects of organophosphorus pesticides on the female reproductive system, the effects on sexual cycle and sexual behavior, and the toxic effects on reproductive outcomes, and explores the possible mechanism of reproductive toxicity.