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为了判断慢性阻塞性肺部疾病（ＣＯＰＤ）的家族聚集性，探讨遗传因素对ＣＯＰＤ发病的影响，分析了２０６对核心家系的资料。结果表明：ＣＯＰＤ的发病具有家族聚集性。ＣＯＰＤ先证者的亲属（父母、兄弟姐妹）患ＣＯＰＤ的危险性增加，是对照家系亲属（父母、兄弟姐妹）的２．０７倍。除母亲之外，两家系父亲间，兄弟间及姐妹间患ＣＯＰＤ危险性的差异均具有显著性。故ＣＯＰＤ先证者的亲属对ＣＯＰＤ的易感性比对照的亲属高，说明遗传因素是ＣＯＰＤ的危险因素之一。
In order to determine familial aggregation in patients with chronic obstructive pulmonary disease (COPD) and to explore the impact of genetic factors on the pathogenesis of COPD, data on 206 core family members were analyzed. The results show that: the incidence of COPD with familial aggregation. COPD proband relatives (parents, siblings) increased the risk of COPD, 2.07 times that of the relatives of family members (parents, siblings). Except for the mothers, there was significant difference in the risk of COPD among the fathers, siblings and sisters. Therefore, the relatives of COPD probands COPD susceptibility than the relatives of the control group, indicating that genetic factors is one of the risk factors for COPD.