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目的测定Beagle犬异氟醚注射液(8%,容积比)最低肺泡有效浓度(MAC静脉),观察其诱导对循环的影响,并与异氟醚吸入最低肺泡有效浓度(MAC吸入)进行比较。方法将Beagle犬12只随机分为异氟醚注射液静脉组(静脉组)和异氟醚吸入组(吸入组)。采用上下法和夹尾刺激测定两组的MAC。监测并记录诱导前及诱导期间的MAP、HR和SpO2变化。结果MAC静脉(1.08±0.16)%明显小于MAC吸入(1.35±0.10)%(P<0.05)。静脉组诱导开始至插管所需时间短于吸入组(P<0.01),且静脉组异氟醚平均诱导用量明显少于吸入组(P<0.01);静脉组停药至拔管时间和停药至站立时间均短于吸入组(P<0.01)。吸入组插管后即刻的MAP和HR均高于插管前(P<0.05),而静脉组插管后即刻的MAP和HR与插管前相比差异无统计学意义。结论MAC静脉明显小于MAC吸入。与吸入异氟醚相比,异氟醚注射液静脉诱导速度快、用药量少、苏醒快、气管插管反应轻。
OBJECTIVE To determine the minimum effective alveolar concentration (MAC) of isoflurane injection (8% volume ratio) in beagle dogs and observe the effect of induction on circulation. The effect of isoflurane inhalation on the lowest alveolar concentration (MAC inhalation) was compared. Methods Twelve Beagle dogs were randomly divided into isoflurane group (intravenous group) and isoflurane group (inhaled group). The MAC of the two groups was determined by the upper and lower methods and the tailgating stimulation. Monitor and record changes of MAP, HR and SpO2 before and during induction. Results MAC vein (1.08 ± 0.16)% was significantly less than MAC (1.35 ± 0.10)% (P <0.05). The time required for initiation of intubation in the venous group was shorter than that in the inhaled group (P <0.01), and the average induction dose of isoflurane in the venous group was significantly less than that in the inhaled group (P <0.01) Drug to stand time were shorter than inhalation group (P <0.01). MAP and HR immediately after intubation were higher than those before intubation (P <0.05). There was no significant difference in MAP and HR immediately after intubation between intubation and intubation. Conclusion MAC vein was significantly less than MAC inhalation. Compared with inhaled isoflurane, intravenous induction of isoflurane injection speed, less medication, wake up fast, light tracheal intubation.