肝病至今仍是人类沉重的健康负担和五大死亡原因之一,肝病的发病率及其相关死亡至今及在不久的将来亦无减轻的迹象,究其原因主要为肥胖、糖尿病和酒精滥用的流行。当前,脂肪性肝病的患病率增长迅猛,而其危害除影响肝脏外,还涉及糖尿病、动脉粥样硬化相关性心脑肾疾病以及肝外恶性肿瘤。作为重要的慢性非传染性疾病,脂肪性肝病现已取代病毒性肝炎成为全球第一大肝病,对人类健康和社会发展构成严重危害。脂肪性肝病的 Liver disease is still a heavy burden of health and one of the top five causes of death in humans. The incidence of liver disease and its related deaths have not shown any significant reduction so far and in the near future, mainly due to the prevalence of obesity, diabetes and alcohol abuse. Currently, the prevalence of fatty liver disease is increasing rapidly, and its harm not only affects the liver, but also involves diabetes, atherosclerotic heart and kidney disease associated with extrahepatic malignancies. As an important chronic non-communicable disease, fatty liver disease has now replaced viral hepatitis as the world’s largest liver disease, posing a serious threat to human health and social development. Fatty liver disease