目的探讨促甲状腺激素受体抗体(Thyrotropin Receptor Antibody,TRAb)和甲状腺过氧化物酶抗体(Thyroid Peroxidase Antibody,TPOAb)测定对格雷夫斯病(Gravse病,GD)的诊断价值。方法用放射受体分析法(Radio Receptor Assay,RRA)对75例初诊GD患者,99例未控制的GD患者,112例经抗甲状腺药物治疗缓解的GD患者,23例GD复发患者,56例健康体检者分别进行TRAb和TPOAb的测定。结果 GD初诊组、未控制组、复发组TRAb水平和阳性率均显著高于GD控制组(P<0.05),GD控制组TRAb水平和阳性率显著高于正常对照组(P<0.05),差异均有统计学意义。GD患者各组TPOAb水平和阳性率均显著高于正常对照组(P<0.05)。结论检测血清TRAb和TPOAb水平在GD发病、进展及复发具有重要的临床意义。 Objective To investigate the diagnostic value of Thyrotropin Receptor Antibody (TRAb) and Thyroid Peroxidase Antibody (TPOAb) in Graves’ Disease (GD). Methods 75 cases of newly diagnosed GD, 99 cases of uncontrolled GD, 112 cases of GD treated with antithyroid drugs, 23 cases of GD recurrence and 56 cases of healthy controls were studied by Radio Receptor Assay (RRA) The subjects were tested for TRAb and TPOAb respectively. Results The levels of TRAb and the positive rate in newly diagnosed group, uncontrolled group and relapsed group were significantly higher than those in GD control group (P <0.05). The levels of TRAb and positive rate in GD control group were significantly higher than those in normal control group (P <0.05) All have statistical significance. The level of TPOAb and the positive rate of each group in GD patients were significantly higher than those in normal control group (P <0.05). Conclusion Detection of serum TRAb and TPOAb levels in the pathogenesis of GD, progression and recurrence has important clinical significance.