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目的 :研究抗高血压药物对自发性高血压大鼠 (SHR)勃起功能和神经元型一氧化氮合酶 (nNOS)神经纤维的影响。 方法 :18只 6周龄雄性SHR随机均分为 3组 :缬沙坦 [30mg (kg·d) ]干预组、螺内酯 [2 0mg (kg·d) ]干预组和对照组。 12周后 ,观察大鼠阴茎勃起功能 ,并用免疫组化SP法检测阴茎组织中nNOS神经纤维的数目。 结果 :缬沙坦干预组勃起次数与另外两组相比差异有显著性 (P <0 .0 5 ) ,后两组之间差异无显著性 (P >0 .0 5 ) ,勃起率 3组之间差异不明显 (P >0 .0 5 ) ,阴茎组织中nNOS神经纤维数目 ,两干预组与对照组之间差异有显著性 (P <0 .0 1) ,而两干预组之间差异无显著性 (P >0 .0 5 )。 结论 :缬沙坦能改善SHR的勃起功能 ,而螺内酯无改善作用 ,这种差异与nNOS神经纤维数目无关 ,可能与血管紧张素Ⅱ(AngⅡ)受体阻滞剂引起血管重构等其他作用有关
Objective: To investigate the effects of antihypertensives on erectile function and neuronal nitric oxide synthase (nNOS) nerve fibers in spontaneously hypertensive rats (SHRs). METHODS: Eighteen 6-week-old male SHRs were randomly divided into three groups: intervention group (30 mg, kg · d) and spironolactone (20 mg · kg -1)] and control group. After 12 weeks, the erectile function of the penis was observed and the number of nNOS nerve fibers in the penile tissue was detected by immunohistochemical SP method. Results: The number of erection in valsartan intervention group was significantly different from that in the other two groups (P <0.05), but there was no significant difference between the two groups (P> 0.05) (P> 0.05). The number of nNOS nerve fibers in the penile tissue was significantly different between the two intervention groups and the control group (P <0.01), while the differences between the two intervention groups No significant (P> 0.05). CONCLUSION: Valsartan can improve the erectile function of SHR without any effect on spironolactone, which is not related to the number of nNOS nerve fibers, which may be related to other effects such as vascular remodeling induced by angiotensin Ⅱ receptor blocker