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目的观察血清免疫球蛋白检验在肝衰竭患者中的临床意义。方法 58例慢性乙型肝炎肝衰竭患者,按照病情程度分为研究组(肝衰竭)与对照组(轻度衰竭),各29例。两组均行血清免疫球蛋白检验并比较,在此基础上分析其关系。结果研究组免疫球蛋白(Ig)G、Ig M、Ig A分别为(28.02±3.68)、(12.50±2.05)、(13.28±2.31)g/L,血清总胆红素(TBi L)、凝血酶原活动度(PTA)、白蛋白(ALB)分别为(582.31±150.10)μmol/L、(32.18±10.21)%、(18.92±5.62)g/L;对照组分别为(9.52±2.01)g/L、(3.04±1.05)g/L、(3.62±1.12)g/L、(31.02±8.37)μmol/L、(85.01±9.62)%、(42.30±2.09)g/L。研究组免疫球蛋白Ig G、Ig M、Ig A、TBi L高于对照组(P<0.05),PTA、ALB低于对照组(P<0.05)。研究组发病1~10 d,Ig G、Ig M、Ig A、TBi L、PTA、ALB分别为(18.12±3.25)g/L、(5.98±2.18)g/L、(5.67±2.10)g/L、(501.21±125.25)μmol/L、(38.01±15.28)%、(18.95±6.32)g/L。发病31~45 d分别为(9.01±1.25)g/L、(2.10±0.25)g/L、(2.30±0.36)g/L、(110.38±62.37)μmol/L、(69.27±12.30)%、(31.85±6.79)g/L。研究组不同时期各项指标随着病情延长而发生改变,差异有统计学意义(P<0.05)。结论血清Ig检验在肝衰竭患者中具有较高的应用价值,有助于患者获得更好地治疗,值得推广。
Objective To observe the clinical significance of serum immunoglobulin test in patients with liver failure. Methods 58 cases of chronic hepatitis B patients with liver failure were divided into study group (liver failure) and control group (mild failure), with 29 cases in each group. Serum immunoglobulin was tested and compared in both groups, and the relationship was analyzed on the basis of this. Results The levels of G, Ig M and Ig A in the study group were (28.02 ± 3.68), (12.50 ± 2.05), (13.28 ± 2.31) g / L, TBiL The activities of PTA and ALB were (582.31 ± 150.10) μmol / L, (32.18 ± 10.21)% and (18.92 ± 5.62) g / L, respectively, and those in the control group were (9.52 ± 2.01) g /L ,(3.04 ± 1.05)g/L, (3.62 ± 1.12) g / L, (31.02 ± 8.37) μmol / L, (85.01 ± 9.62)%, (42.30 ± 2.09) g / L. The immunoglobulin Ig G, Ig M, Ig A and TBi L of the study group were higher than those of the control group (P <0.05), PTA and ALB were lower than those of the control group (P <0.05). The incidence of IgA, IgM, IgA, TBiL, PTA and ALB in the study group were (1.12 ± 3.25) g / L, 5.98 ± 2.18g / L and 5.67 ± 2.10g / L, (501.21 ± 125.25) μmol / L, (38.01 ± 15.28)% and (18.95 ± 6.32) g / L, respectively. The incidence of asthma was (9.01 ± 1.25) g / L, (2.10 ± 0.25) g / L and (2.30 ± 0.36) g / L respectively in the period of 31-45 days (110.38 ± 62.37) μmol / L and (69.27 ± 12.30) (31.85 ± 6.79) g / L. The research group at different times with various indicators of the disease has changed, the difference was statistically significant (P <0.05). Conclusion Serum Ig test has high value in patients with liver failure, which will help patients get better treatment and is worth promoting.