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应用免疫组化方法研究胆管癌组织中ＥＭＡ、ＣＫ表达及其意义。４２例胆管癌ＥＭＡ阳性２２例（５４．８％）和ＣＫ阳性３２例（７６．２％），高分化腺癌ＥＭＡ、ＣＫ阳性率及半定量分极较明显高于低分化腺癌和未分化癌；２０例癌旁上皮ＥＭＡ阳性１８例和ＣＫ均阳性，而其癌组织ＥＭＡ阳性１３例和ＣＫ阳性１７例；转移组ＥＭＡ、ＣＫ阳性率较低于未转移组。结果提示ＥＭＡ、ＣＫ可能是反映胆管癌生物学行为的重要标记物，ＥＭＡ、ＣＫ阴性胆管癌可能预后不良。
Immunohistochemistry was used to study the expression of EMA and CK in cholangiocarcinoma and its significance. In 42 cases of cholangioma, 22 cases (54.8%) were positive for EMA, and 32 cases (76.2%) were positive for CK. The positive rates and semi-quantitative levels of EMA, CK in well-differentiated adenocarcinoma were significantly higher than those in poorly differentiated adenocarcinoma. Differentiation cancer; 20 cases of positive EMA were positive for EMA in the adjacent epithelium, while 13 cases were positive for EMA and 17 cases were positive for CK. The positive rate of EMA and CK in the metastatic group was lower than that in the non-metastatic group. The results suggest that EMA and CK may be important markers reflecting the biological behavior of cholangiocarcinoma, and EMA and CK-negative cholangiocarcinoma may have a poor prognosis.