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目的探讨白三烯受体拮抗剂联合沙美特罗替卡松治疗老年支气管哮喘患者的临床疗效。方法选取2014年4月至2015年3月内江市市中区人民医院收治的98例老年哮喘患者作为研究对象,按随机数字表法将其分为观察组和对照组,各49例。对照组患者采用沙美特罗替卡松进行治疗,观察组患者在对照组基础上睡前口服孟鲁司特钠咀嚼片,比较两组患者的临床疗效、肺功能、不良反应发生情况。结果观察组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后,观察组患者的最大呼气流量(PEF)、第1秒钟用力呼气容积(FEV1)、用力肺活量(FVC)及FEV1/FVC均明显高于对照组,差异均有统计学意义(均P<0.05)。结论白三烯受体拮抗剂联合沙美特罗替卡松治疗老年支气管哮喘患者,可有效提高临床疗效,改善患者肺功能,是安全而理想的治疗方式。
Objective To investigate the clinical efficacy of leukotriene receptor antagonist combined with salmeterol and fluticasone in elderly patients with bronchial asthma. Methods A total of 98 elderly patients with asthma who were treated in Zhongjiang People’s Hospital, Neijiang City from April 2014 to March 2015 were selected as subjects and divided into observation group and control group according to random number table. Patients in the control group were treated with salmeterol and fluticasone. The patients in the observation group were given oral montelukast sodium chewable tablets on the basis of the control group. The clinical efficacy, pulmonary function and adverse reactions of the two groups were compared. Results The total effective rate of observation group was significantly higher than that of control group (P <0.05). After treatment, the maximum expiratory flow rate (PEF), forced expiratory volume of 1 second FEV1), forced vital capacity (FVC) and FEV1 / FVC were significantly higher than those in the control group (all P <0.05). Conclusion Leukotriene receptor antagonist combined with salmeterol and fluticasone in the treatment of elderly patients with bronchial asthma, which can effectively improve clinical efficacy and improve lung function, is a safe and ideal treatment.