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目的:探讨恶性肿瘤特异生长因子(TSGF)、γ-谷氨酰转移酶(GGT)、甲胎蛋白(AFP)联合诊断原发性肝癌(HCC)的临床价值。方法:采集2013年6月至2015年6月本院180例血清样本,其中HCC患者80例,肝硬化50例,健康对照组50例,测定3组研究对象的血清TSGF、GGT、AFP水平。结果:3组研究对象血清TSGF、AFP、GGT比较,差异具有统计学意义(P<0.05)。HCC组血清TSGF、AFP显著高于肝硬化组、健康对照组(P<0.05),肝硬化组血清TSGF、AFP显著高于健康对照组(P<0.05)。肝硬化组血清GGT显著高于HCC组(P<0.05),HCC组血清GGT显著健康对照组(P<0.05)。TSGF、AFP、GGT联合检测时敏感性90%,特异性85%、阳性预测值91%,显著优于上述3项的单项指标检测(P<0.05)。结论:与AFP单项相比,TSGF、AFP、GGT 3者联合诊断原发性肝癌敏感性、特异性更高,能显著提高HCC阳性检出率,临床诊断意义更显著。
Objective: To investigate the clinical value of combination of TSGF, GGT and AFP in the diagnosis of primary hepatocellular carcinoma (HCC). Methods: A total of 180 serum samples were collected from June 2013 to June 2015 in our hospital, including 80 HCC patients, 50 cirrhosis and 50 healthy controls. Serum levels of TSGF, GGT and AFP were measured in 3 subjects. Results: The differences of serum TSGF, AFP and GGT between the three groups were statistically significant (P <0.05). The levels of serum TSGF and AFP in HCC group were significantly higher than those in cirrhosis group and healthy control group (P <0.05). The levels of serum TSGF and AFP in cirrhosis group were significantly higher than those in healthy control group (P <0.05). Serum GGT in cirrhosis group was significantly higher than that in HCC group (P <0.05), serum GGT level in HCC group was significantly higher than that in HCC group (P <0.05). TSGF, AFP, GGT combined detection of 90% sensitivity, specificity 85%, positive predictive value 91%, significantly better than the above three single index test (P <0.05). Conclusion: Compared with AFP alone, TSGF, AFP and GGT 3 are more sensitive and specific for the diagnosis of primary liver cancer, which can significantly increase the positive detection rate of HCC and have a more significant clinical diagnosis.