1,2-二硫戊环(1,2-dithiolane)类天然产物是1类特殊的五元杂环类化合物。由于五元环的张力比较大,使其具有良好的反应活性;又因为硫环容易开环成巯基,使其具有较强的抗氧化能力,可以清除过多的氧自由基,维持体内自由基的平衡。因此,1,2-二硫戊环类天然产物得到了生物医学界越来越多的关注。本文综述了4类含有1,2-二硫戊环结构的天然产物,包括海洋天然产物二硫吡咯酮抗生素(dithiolopyrrolone antibiotic)、kottamide E以及硫辛酸(lipoic acid)和芦笋酸(asparagusic acid),综述了它们的研究历程、生物活性或应用以及主要的合成方法。 1,2-dithiolane (1,2-dithiolane) natural product is a class of special five-membered heterocyclic compounds. Due to the relatively large tension of the five-membered ring, it has good reactivity; and because the sulfur ring is easily opened to the mercapto group, which has strong antioxidant capacity, can remove excess oxygen free radicals and maintain body free radicals Balance. Therefore, 1,2-dithiolane natural products have been the biomedical community more and more attention. Four types of natural products containing 1,2-dithiolane structure are reviewed, including the marine natural product dithiolopyrrolone antibiotic, kottamide E and lipoic acid and asparagusic acid, The research progress, biological activity or application as well as the main synthesis methods are reviewed.