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目的现场评价日本血吸虫中国大陆株对吡喹酮的敏感性。方法在云南、江苏、江西、湖南和湖北等5个省的血吸虫病流行区,选择11个村作为调查现场。在血吸虫病非传播季节,采用粪检法(Kato-Katz法和/或尼龙袋集卵孵化法)筛选出病人;以吡喹酮40mg/kg一次顿服对粪检阳性病人实施抗血吸虫治疗;治疗后6周采用相同方法复查粪便;阳性者仍按40mg/kg吡喹酮顿服进行第2次治疗;首次治疗后12周,对所有已治者(包括第2次治疗者)进行再次粪便复查。结果在11个流行村共粪检村民4760人,阳性者584人,其中505人经吡喹酮首次治疗后6周复查粪便,480人转阴,治愈率为95.1%;21例首次治疗后粪检仍然阳性者予以第2次治疗。在首次治疗后12周,对所有已治者(包括第2次治疗者)进行再次粪便复查,未发现粪检阳性者。结论尽管在我国血吸虫病主要流行区采用吡喹酮实施大规模化疗已达10余年,但现场至今尚未发现日本血吸虫中国大陆株对吡喹酮敏感性下降的证据。
Objective To evaluate the sensitivity of Schistosoma japonicum to praziquantel in China. Methods 11 schistosomiasis endemic areas in 5 provinces including Yunnan, Jiangsu, Jiangxi, Hunan and Hubei were selected as the survey site. Patients were screened by the fecal method (Kato-Katz method and / or nylon bag-hatching method) during the non-transmission period of schistosomiasis; anti-schistosome treatment with a praziquantel 40 mg / kg once- The same method was used to examine the faeces 6 weeks after the treatment. The positive patients were still treated with praziquantel 40 mg / kg for the second time. After the first 12 weeks of treatment, all those who had been treated (including the second treatment) Review. Results Among the 11 endemic villages, 4,760 villagers were fecal seized, 584 were positive. Among them, 505 were reexamined 6 weeks after praziquantel treatment for the first time and 480 were negative, the cure rate was 95.1%; 21 cases were treated for the first time The test is still positive for the second treatment. At 12 weeks after the first treatment, all those who have been treated (including the second treatment) were re-stool examination, found no positive stool. Conclusion Although praziquantel has been used in large-scale chemotherapy in the endemic areas of schistosomiasis in China for more than 10 years, no evidence of the decreased susceptibility of Schistosoma japonicum to praziquantel has been found in China so far.