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吞噬细胞NADPH氧化酶是一个多组分活化的酶复合体,是吞噬细胞抗菌系统的主要成分。此氧化酶体系包括膜结合的和可溶的胞浆蛋白,其主要特征为依赖刺激而活化,机制为复合体的胞浆因子磷酸化并转位至膜,在这里与细胞色素酶相关联,组装完全的复合体在功能上作为一个电子转运体系,从胞浆NADPH转移电子给分子氧形成超氧阴离子(O2-),伴随着接下来的活性物质产生,也叫呼吸爆发,发挥抗菌和抗细胞毒素的活性。NADPH氧化酶的这一活化过程受调节亚基、上游调节子等多重因素的调控。
Phagocyte NADPH oxidase is a multi-component activated enzyme complex that is a major component of the phagocyte antimicrobial system. This oxidase system includes membrane-bound and soluble cytoplasmic proteins, the main feature of which is activation-dependent stimulation by the mechanism by which the cytoplasmic factor of the complex phosphorylates and translocates to the membrane where it is associated with a cytochrome enzyme , The fully assembled complex functionally acts as an electron transport system that transfers electrons from cytoplasmic NADPH to molecular oxygen to form superoxide anion (O2-), which is accompanied by the subsequent generation of an active substance, also known as respiratory burst, exerting antimicrobial and Anti-cytotoxin activity. This activation of NADPH oxidase is regulated by multiple factors such as regulatory subunits, upstream regulators and the like.