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世界银行贷款中国结核病控制项目在辽宁省１０个县进行实施性研究。１２５２例初、复治涂阳肺结核病例的调查表明，用组合药的抱怨率分别为８．１％及７．７％，明显低于散装药组的１７．８％及２６．２％（Ｐ＜０．０１）。９３．９％用组合药组的医生认为组合药使用方便，而用散装药组只有５４．５％认为散装药也方便（Ｐ＜０．０１）。虽然在项目严格的管理条件下组合药未能显示提高治愈率的作用，但是组合药具有的改善农村广大病人用药顺从性，便于监督管理，不易发生药品配伍和剂量差错等潜在优势。
The World Bank Loan TB Control Project in China conducts a pilot study in 10 counties in Liaoning Province. A survey of 1252 cases of initial and retreatment smear-positive pulmonary tuberculosis showed that the complainant rates of combination drugs were 8.1% and 7.7% respectively, significantly lower than those of the bulk drug group of 17.8% and 26.2% (P <0.01). 93.9% of the patients in the combined drug group considered the combination to be easy to use, while only 54.5% of the bulk drug users considered the bulk drug convenient (P <0.01). Although the combination of drugs failed to show the effect of improving the cure rate under the strict management conditions of the project, the combination drug has the potential to improve drug compliance of the majority of patients in rural areas, facilitate supervision and management, and is not prone to drug compatibility and dose errors.