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目的探讨垂体催乳素腺瘤中半乳凝素-3-mRNA(Galectin-3-mRNA)表达与腺瘤的临床生物学行为之间的关系。方法选择32例经蝶显微手术切除的垂体催乳素腺瘤患者标本,分侵袭组与非侵袭组,采用显色原位杂交法(CISH)检测石蜡切片标本中Galectin-3蛋白的mRNA。以非参数检验对两种方法检测结果的相关性进行分析。结果侵袭性与Galectin-3的mRNA表达呈显著性相关(相关系数=0.893 P<0.01);Galectin-3-mRNA与血浆PRL水平、腺瘤体积大小相关(相关系数=0.593,0.522 P<0.05)。结论Galectin-3-mRNA表达与对判断侵袭性催乳素腺瘤体积大小、侵袭、血清PRL水平可能有一定的参考价值。
Objective To investigate the relationship between the expression of galectin-3-mRNA (Galectin-3-mRNA) and the clinical biological behavior of pituitary adenoma. Methods Thirty-two specimens of pituitary prolactinoma resected by microsurgical microsurgery were divided into invasive group and noninvasive group. The expression of Galectin-3 mRNA in paraffin sections was detected by chromogenic in situ hybridization (CISH). The nonparametric test was used to analyze the correlation between the two methods. RESULTS: The expression of Galectin-3 mRNA was significantly correlated with invasiveness (correlation coefficient = 0.893, P <0.01). Galectin-3 mRNA was correlated with plasma PRL level and adenoma volume (correlation coefficient = 0.593, 0.522, P < . Conclusion The expression of Galectin-3-mRNA may be useful for judging the size, invasion and serum PRL of aggressive prolactinoma.