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目的探讨血液病患者血小板无效输注的免疫因素。方法以血小板计数增高指数判断234名血液病患者的493人次单采血小板输注效果,采用SEPSA法检测输注后的血小板抗体,分析讨论血小板无效输注的免疫因素。结果不同疾病类型血液病患者的血小板无效输注率及抗体检出率的差异有统计学意义(P<0.05)。血液病血小板输注有效组与无效组的抗体阳性检出率的差异有统计学意义(P<0.01)。血小板抗体的产生与性别、年龄无关。有22名患者的血小板抗体出现减弱或消失。结论血小板输注前应进行血小板抗体的筛选,避免或减少造成血小板输注无效的原因,提高血小板输注的有效率。
Objective To investigate the immune factors of platelet invalid infusion in patients with hematological diseases. Methods The platelet count index was used to determine the effect of 493 single platelet transfusion in 234 patients with blood diseases. The antibody of platelet after infusion was detected by SEPSA, and the immune factors of invalid platelet transfusion were analyzed. Results There was a significant difference in the rate of invalid platelet transfusion and antibody detection between patients with different types of blood diseases (P <0.05). There was a significant difference in the positive detection rate of antibodies between the effective and inactive blood platelet transfusion patients (P <0.01). Platelet antibody production and sex, age has nothing to do. 22 patients with platelet antibodies appear weakened or disappeared. Conclusion Platelet transfusion should be carried out before the screening of platelet antibodies to avoid or reduce the causes of ineffective platelet transfusion and improve the efficiency of platelet transfusion.