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就皮肤原发鳞癌来看,表面局部光敏剂与便携式非激光光源联合应用和通常治疗方法相比二者治疗效果相同。作者对VIN和CIN光动力学治疗(PDT)的安全性和有效性进行了评价。6名将进行切除术的妇女,病灶局部涂抹致光敏因子5-氨基乙酰丙酸(5-ALA)(20％软膏)4h。为观察5-ALA的渗透性和转化成活性光敏剂原卟啉Ⅸ,在VIN和CIN患者病灶局部取活检,并立即作冰冻切片,在低能光源条件下用荧光显微镜进行观察;结果在上皮全层,荧光均匀且强度相同。接着对18名晚期VIN
In the case of primary cutaneous squamous cell carcinoma, the combination of topical topical photosensitizers with portable non-laser light sources and the usual treatment methods have the same therapeutic effect. The authors evaluated the safety and efficacy of VIN and CIN photodynamic therapy (PDT). Six women who underwent resections were treated with topical photosensitizing 5-aminolevulinic acid (5-ALA) (20% ointment) for 4 hours. In order to observe the permeability of 5-ALA and convert it into the active photosensitizer protoporphyrin IX, a biopsy was taken locally in the lesions of VIN and CIN patients, and immediately frozen sections were taken and observed under a low-energy light source with a fluorescence microscope; the result was observed in the epithelium. The layer has uniform fluorescence and the same intensity. Then 18 late VINs