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非稳态负荷作为一个反映应激状态下人体各项生理系统累积磨损的综合指标，其水平的异常与抑郁症发病相关。本文系统介绍了非稳态负荷的概念和分类及国内外相关研究，分析了非稳态负荷与不同年龄、不同种族、不同性别抑郁症患者发病的关联性，探讨了非稳态负荷作为抑郁症患病风险预测因子的可能性，为进一步探索抑郁症的发病机制提供一定的理论基础。“,”As a multi-system index reflecting cumulative wear-and-tear on the body driven by stress, the abnormal of allostatic load (AL) is related to the onset of depression. This paper systematically introduced the concept and classification of allostatic load and the related research at home and abroad, analyzed the correlation between the allostatic load and depression in patients with different ages, races and genders, elucidated its possibility as a risk predictor， and provided a certain theoretical basis for further explorations regarding the pathogenesis of depression.