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目的探讨慢性胃炎(CG)和消化性溃疡(PU)与幽门螺杆菌(Hp)感染的关系。方法将有上腹隐痛、饱胀不适、反酸、嗳气等上消化道症状,经胃镜诊断为慢性胃炎的252例、消化性溃疡的80例患者作为观察组;将无消化系统症状,正常体检做胃镜检查者102例作为对照组。2组患者分别在病变部位、溃疡周围及胃窦部处取活组织,用苏木素-伊红(HE)染色确定活动期。经改良Giemsa染色查Hp。结果 CG及PU患者Hp感染总检出率(61.5%)与对照组Hp总检出率(26.5%)相比,有显著性差异(P<0.01)。活动期消化性溃疡Hp检出率(94.0%)高于非活动期消化性溃疡(38.5%),2组有显著性差异(P<0.01)。结论 CG和PU的发生与幽门螺杆菌(Hp)感染有密切关系。
Objective To investigate the relationship between chronic gastritis (CG) and peptic ulcer (PU) and Helicobacter pylori (Hp) infection. Methods 252 cases of upper gastrointestinal pain, fullness discomfort, acid reflux, belching and other upper gastrointestinal symptoms, gastroscopy diagnosed as chronic gastritis and 80 cases of peptic ulcer were selected as the observation group. The patients without digestive system symptoms and normal physical examination Gastroscopy to do 102 cases as a control group. The patients in the two groups took the living tissue around the lesion, around the ulcer and at the antrum, and determined the activity period by hematoxylin-eosin (HE) staining. Improved Giemsa staining Hp. Results The overall prevalence of Hp infection in CG and PU patients was significantly higher than that in controls (61.5% vs. 26.5%, P <0.01). The detection rate of active peptic ulcer Hp (94.0%) was higher than inactive peptic ulcer (38.5%), there was significant difference between the two groups (P <0.01). Conclusions The occurrence of CG and PU is closely related to Helicobacter pylori (Hp) infection.