论文部分内容阅读
巨噬细胞清除机体内免疫复合物(IC)的方式有二:①直接通过Fc受体与IC结合,②间接通过补体受体与IC结合.有些IC有特殊的致病性,可在循环中长久存在并导致人及实验动物的血管炎.循环IC(CIC)的清除速率与单一核细胞吞噬系统(MPS)的活性有关.近来Frank等测定脾MPS细胞膜上的IgG-Fc受体功能.表明SLE和Sjogren综合征患者的Fc受体功能显著低下,与疾病的活动性和CIC的水平相关.为了探讨血管炎的发病机制有无类似情况,作者进行以下实验.本文用~(51)Cr标记的IgG抗Rh(D)包裹的自
Macrophages clear the body’s immune complex (IC) in two ways: ① directly through the Fc receptor and IC binding, ② indirectly through the complement receptor and IC binding. Some IC has a special pathogenicity, in the cycle Permanently occurring and leading to vasculitis in humans and laboratory animals, the rate of elimination of circulating IC (CIC) is related to the activity of the mononuclear phagocytic system (MPS). Recently Frank et al. Determined IgG-Fc receptor function in the splenic MPS cell membrane, Fc receptor function in patients with SLE and Sjogren’s syndrome is significantly lower and correlates with disease activity and CIC level.In order to investigate whether the pathogenesis of vasculitis is similar or not, we performed the following experiment: IgG anti-Rh (D) self-packaged