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目的探讨原发性肺癌患者血清中癌抗原125(CA125)、骨胶素(CY211)、癌胚抗原(CEA)、鳞状上皮细胞癌抗原(SCC)及神经元特异性烯醇化酶(NSE)的变化及其意义。方法选取2014年10月至2015年12月间临汾市人民医院就诊的50例肺癌者(A组)、50例肺良性疾病患者(B组),另选同期体检的健康人50名作为对照组,采用化学发光法检测3组肿瘤标志物的表达水平。结果 A、B两组各项肿瘤标志物水平明显高于对照组,差异有统计学意义(P<0.05)。A组患者CEA和CY211水平明显高于B组,差异有统计学意义(P<0.05)。与临床手术组织病理检查结果比较,小细胞肺癌患者NSE阳性率较其他类型肺癌高,而腺癌患者中CA125阳性率最高,鳞癌患者中CY211阳性率表达最高。结论检测肿瘤标志物,尤其是血清CEA和CY211可有利于肺癌的诊断及肺癌患者临床病理分型,可为临床治疗提供指导价值。
Objective To investigate the changes of serum levels of CA125, CY211, CEA, SCC and NSE in patients with primary lung cancer Change and its significance. Methods Fifty patients with lung cancer (group A) and 50 patients with benign lung disease (group B) were enrolled in this study from October 2014 to December 2015. Fifty healthy subjects were selected as the control group The chemiluminescence method was used to detect the expression level of three tumor markers. Results The tumor markers in group A and group B were significantly higher than those in control group (P <0.05). The level of CEA and CY211 in group A was significantly higher than that in group B, the difference was statistically significant (P <0.05). The positive rate of NSE in patients with small cell lung cancer was higher than that of other types of lung cancer. The positive rate of CA125 in patients with adenocarcinoma was the highest, while the positive rate of CY211 in patients with squamous cell carcinoma was the highest. Conclusion Detecting tumor markers, especially serum CEA and CY211, can be helpful for the diagnosis of lung cancer and the clinicopathological type of lung cancer, which may provide the guiding value for clinical treatment.