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目的探讨帕金森病(PD)患者认知功能和血浆半胱氨酸的关系,为PD的临床寻找更多的实验室依据。方法对50例PD患者和48例正常人分别进行了事件相关电位(ERP)和血浆半胱氨酸水平的测定,并将结果加以比较。结果 PD组中ERP测定的异常率为94.0%(47/50),ERP中N2、P3波潜伏期较对照组延长,P3波幅降低,其差异具有统计学意义(t=3.141,3.771,5.622;P<0.01),血浆半胱氨酸水平增高,与对照组相比差异具有统计学意义(t=3.924,P<0.01)。PD组ERP成分中P3波潜伏期与血浆半胱氨酸水平呈正相关(r=0.43,P<0.01),而P3波幅与其呈负相关(r=-0.46,P<0.01)。结论 PD患者存在明显的认知功能障碍及血浆半胱氨酸水平增高,且两者相互影响,ERP和血浆半胱氨酸水平测定可作为PD患者临床判定指标。
Objective To investigate the relationship between cognitive function and plasma cysteine in patients with Parkinson’s disease (PD) and to find more laboratory evidences for PD. Methods 50 cases of PD patients and 48 normal subjects were measured for ERP and plasma cysteine levels, and the results were compared. Results The abnormal rate of ERP in PD group was 94.0% (47/50). The latent period of N2 and P3 wave in ERP group was longer than that in control group, and the amplitude of P3 was decreased. The difference was statistically significant (t = 3.141, 3.771, 5.622; P <0.01), plasma cysteine levels increased compared with the control group, the difference was statistically significant (t = 3.924, P <0.01). There was a positive correlation between P3 wave latency and plasma cysteine level in PD group (r = 0.43, P <0.01), while P3 amplitude was negatively correlated with it (r = -0.46, P <0.01). Conclusion PD patients have obvious cognitive dysfunction and plasma cysteine levels increased, and the interaction between the two, ERP and plasma cysteine levels can be used as clinical indicators of PD patients.