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目的:研究口腔白斑念珠菌感染的临床和病理学特征。方法:利用过碘酸雪夫染色诊断念珠菌感染,回顾性分析448例白斑患者的活检组织中念珠菌感染率,并分析年龄、性别、白斑病损部位、白斑上皮异常增生等因素与感染的关系。结果:白斑组织中念珠菌的感染率14.1%。念珠菌性白斑比普通型白斑的上皮异常增生发生率更高(57.1%vs.33.8%)。回归分析显示>60岁的老年患者、舌部白斑和上皮异常增生是念珠菌易感因素。结论:念珠菌感染和上皮异常增生密切相关。伴有上皮异常增生的舌部白斑的老年患者更易感染念珠菌。
Objective: To study the clinical and pathological features of Candida albicans infection. Methods: Candida albicans infection was diagnosed by periodic acid Schiff staining. The infection rate of Candida in biopsies of 448 patients with leukoplakia was retrospectively analyzed. The relationship between age, sex, location of vitiligo lesions, abnormal epithelial dysplasia and infection was analyzed . Results: Candida infection in leukoplakia was 14.1%. Candida albino had a higher prevalence of epithelial dysplasia than common white spots (57.1% vs.33.8%). Regression analysis showed that elderly patients> 60 years of age, tongue leukoplakia and epithelial dysplasia are Candida susceptible factors. Conclusion: Candida infection is closely related to epithelial dysplasia. Elderly patients with tongue leukoplakia with epithelial dysplasia are more susceptible to Candida.