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目的:探讨DNA损伤修复酶基因XRCC1Arg194Trp多态性和AGT基因第三外显子Leu84Phe多态性与食管癌易感性的关系。方法:采用病例-对照研究方法分析四川北部地区食管癌病例(n=155)和年龄、性别分布无差异的对照组(n=127)XRCC1基因Arg194Trp多态性和AGT基因第三外显子Leu84Phe多态性,两个基因多态的交互作用和基因多态与吸烟、饮酒之间的交互作用对食管癌易感性的影响。结果:XRCC1基因194位点各基因型在两组间的分布无统计学差异(χ~2=0.614;P=0.736)。AGT基因第三外显子第84位密码子各基因型在两组间的分布无统计学差异(χ~2=1.826;P=0.177),吸烟、饮酒与AGT基因第三外显子第84位密码子突变基因型TT存在正交互作用,交互作用指数(the synergy index S,S)分别为7.375、17.67。结论:四川北部地区XRCC1基因194位点基因多态性与AGT基因第三外显子Leu84Phe多态性可能与食管癌的易感性无关,但AGT基因第三外显子Leu84Phe多态性可能与吸烟、饮酒与食管癌的易感性之间存在协同作用。
Objective: To investigate the relationship between XRCC1Arg194Trp polymorphism of DNA damage repair gene and Leu84Phe polymorphism of exon 3 of AGT gene and susceptibility to esophageal cancer. Methods: A case-control study was performed to analyze the association between Arg194Trp polymorphism of XRCC1 gene and the third exon of Leu84Phe AGT gene in esophageal cancer cases (n = 155) and age- and gender-matched controls in the northern part of Sichuan Province (n = 127) Effects of Polymorphisms, Interactions between Two Gene Polymorphisms and Genetic Polymorphisms and Smoking, Alcohol Interactions on Susceptibility to Esophageal Cancer. Results: There was no significant difference in genotype distribution of 194 loci in XRCC1 gene between the two groups (χ ~ 2 = 0.614; P = 0.736). AGT gene exon 84 codon 84 genotypes in the distribution of the two groups showed no significant difference (χ ~ 2 = 1.826; P = 0.177), smoking, drinking and AGT gene exon 84 There was an orthogonal interaction between the TT genotype TT and the synergy index S (S) of 7.375 and 17.67, respectively. Conclusion: The 194 polymorphism of XRCC1 gene and the Leu84Phe polymorphism of exon 3 of AGT gene may not be related to the susceptibility to esophageal cancer in the northern part of Sichuan Province, but the Leu84Phe polymorphism of the third exon of AGT gene may be associated with smoking There is a synergistic effect between alcohol consumption and esophageal cancer susceptibility.