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目的:探讨2型糖尿病(T2DM)并发冠心病(CHD)患者血浆总同型半胱氨酸(tHcy)、血小板参数(PLT、PCT、MPV、PDW)变化的临床意义。方法:将92例T2DM患者分为无并发CHD组(52例)和并发CHD组(40例),分别检测其血浆tHcy、PLT、PCT、MPV、PDW水平,并与健康对照组(56例)比较。结果:T2DM组的tHcy、MPV、PDW、FPG明显高于对照组(P<0.01),PLT显著低于对照组(P<0.01),PCT与无并发CHD组差异无统计学意义(P>0.05);T2DM并发CHD组tHcy、MPV、PDW明显高于无并发CHD组(P<0.01),PLT显著低于无并发CHD组(P<0.01),PCT、FPG与无并发CHD组差异无统计学意义(P>0.05)。结论:T2DM患者,定期检查血小板参数和tHcy水平,并进行针对性的治疗,将有助于T2DM并发CHD的防治。
Objective: To investigate the clinical significance of plasma total homocysteine (tHcy), platelet parameters (PLT, PCT, MPV, PDW) in patients with type 2 diabetes mellitus (T2DM) complicated with coronary heart disease (CHD) Methods: Totally 92 patients with T2DM were divided into two groups: concomitant CHD group (52 cases) and concurrent CHD group (40 cases). The levels of tHcy, PLT, PCT, MPV and PDW in plasma were detected and compared with those in healthy control group Compare Results: The levels of tHcy, MPV, PDW and FPG in T2DM group were significantly higher than those in control group (P <0.01), PLT was significantly lower than that in control group (P <0.01), but there was no significant difference between PCT and CHD group ). The levels of tHcy, MPV and PDW in patients with T2DM complicated with CHD were significantly higher than those without CHD (P <0.01), PLT was significantly lower than those without CHD (P <0.01), but there was no significant difference between PCT, FPG and non-complicated CHD Significance (P> 0.05). Conclusion: T2DM patients, regular examination of platelet parameters and tHcy levels, and targeted treatment, will contribute to the prevention and treatment of T2DM complicated with CHD.