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目的：研究不含甲硝唑的短程低剂量质子泵抑制剂（ＰＰＩ）三联疗法对幽门螺杆菌（ＨＰ）根除消化性溃疡愈合的疗效。方法：采用随机双盲对照研究。将４７ 例ＨＰ阳性的消化性溃疡患者随机分为２ 组，即Ａ组（低剂量三联）采用达克普隆３０ ｍ ｇ １次／ｄ 加克拉霉素２５０ ｍ ｇ ２ 次／ｄ 加阿莫西林５００ ｍ ｇ ２ 次／ｄ，连服１０ ｄ；Ｂ组（安慰剂）采用胃舒平３片，２ 次／ｄ，连用４ 周，双盲双模拟用药。疗程结束后４ 周复查胃镜。结果：Ａ组ＨＰ根治率和溃疡愈合率分别为９３．３％ 和８６．７％ ，明显高于Ｂ组的０ 和２３．５％ （均Ｐ＜ ０．０５）。前者对症状缓解作用好、速度快，无明显副作用，患者依从性好。结论：短程低剂量ＰＰＩ三联疗法是治疗ＨＰ相关性消化性溃疡较为理想的治疗方案，尤其对甲硝唑耐药者更值得试用
Objective: To study the curative effect of triple therapy of metronidazole-free short-term and low-dose proton pump inhibitor (PPI) on the healing of Helicobacter pylori (HP) in peptic ulcer. Methods: A randomized double-blind controlled study. 47 cases of HP-positive peptic ulcer patients were randomly divided into two groups, namely, group A (low dose triple) with daclopronin 30 m g 1 times / d plus clarithromycin 250 m g 2 times / d plus Amo Xilin 500mg twice a day, and even served 10d; B group (placebo) with stomach Shuping 3 tablets, 2 times / d, once every 4 weeks, double-blind double-dummy medication. Gastroscope was reviewed 4 weeks after the end of treatment. Results: The radical cure rate and ulcer healing rate in group A were 93.3% and 86.7%, respectively, which were significantly higher than those in group B (0 and 23.5%, P <0.05). The former has a good effect on relieving symptoms, is fast, has no obvious side effects, and has good compliance. Conclusion: Short-range, low-dose PPI triple therapy is an ideal treatment for HP-associated peptic ulcer, especially for metronidazole resistant patients