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目的观察泮托拉唑治疗上消化道出血的临床疗效及安全性。方法对162例临床确诊的上消化道出血患者随即双盲分为观察组(80例)和对照组(82例),观察组给予注射用泮托拉唑80mg静脉滴注,2次/d,疗程3～5d,对照组给予法莫替丁20mg静脉滴注,2次/d,疗程3～5d,观察两组给药后72h及120h临床症状改善,实验室指标或内镜下止血征象。结果观察组与对照组,显效率分别为47.50%、26.83%,总有效率分别为96.25%、69.51%,观察组的疗效优于对照组,差异有统计学意义(P<0.05)。结论注射用泮托拉唑治疗上消化道出血效果显著,不良反应轻微,适合临床应用。
Objective To observe the clinical efficacy and safety of pantoprazole in the treatment of upper gastrointestinal bleeding. Methods 162 cases of clinically diagnosed patients with upper gastrointestinal bleeding were randomly divided into observation group (80 cases) and control group (82 cases). The observation group was given intravenous infusion of pantoprazole 80 mg twice daily, The course of treatment was 3 ~ 5 days. The control group was given 20 mg of famotidine for intravenous drip twice a day for 3 ~ 5 days. The clinical symptoms, signs of laboratory or endoscopic hemostasis were observed at 72 and 120 hours after the administration. Results The effective rates of the observation group and the control group were 47.50% and 26.83%, respectively. The total effective rates were 96.25% and 69.51% respectively. The curative effect of the observation group was better than that of the control group (P <0.05). Conclusions Pantoprazole for injection is effective in treating upper gastrointestinal bleeding with mild side effects and is suitable for clinical application.