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目的分析抗肿瘤药物的不良反应(ADR)规律及其特点,为临床合理用药提供参考。方法对我院2009年收集的134例抗肿瘤药物的不良反应报告进行回顾性分析。结果抗肿瘤药物涉及的不良反应以中老年为多,吉非替尼、厄洛替尼、索拉非尼所致不良反应居前三位,皮肤及其附件损害最常见。结论临床上应加强对抗肿瘤药物的监测,以减少或避免不良反应的发生。
Objective To analyze the regularity and characteristics of adverse reactions (ADRs) of anticancer drugs and provide references for clinical rational drug use. Methods A retrospective analysis was made on the adverse reactions of 134 anti-tumor drugs collected in our hospital in 2009. Results The anticancer drugs involved in adverse reactions in the elderly and more, gefitinib, erlotinib, sorafenib caused the top three adverse reactions, the most common damage to the skin and its accessories. Conclusion Clinic should strengthen the monitoring of anti-cancer drugs to reduce or avoid the occurrence of adverse reactions.