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目的探讨高迁移率族蛋白1(HMGB1)及基质金属蛋白酶-9(MMP-9)在子宫内膜癌中的阳性表达率,并分析其相关性。方法选取2015年2月-2016年10月的子宫内膜癌患者60例,取其癌变组织作为子宫内膜癌组,同时取其癌旁正常组织作为癌旁组。另选取同期行子宫切除术的单纯性子宫内膜增生症患者60例作为对照组。检测3组HMGB1及MMP-9阳性表达率并进行比较,分析子宫内膜癌患者HMGB1及MMP-9阳性表达率与年龄、肿瘤直径、是否绝经、FIGO分期、淋巴结转移、分化程度、病理类型和浸润程度的关系,分析HMGB1表达及MMP-9表达的相关性。结果 3组HMGB1和MMP-9阳性率比较差异均有统计学意义(P<0.05)。子宫内膜癌组HMGB1阳性表达率显著高于癌旁组和对照组(P<0.05),子宫内膜癌组MMP-9阳性表达率显著高于癌旁组和对照组(P<0.05)。子宫内膜癌组HMGB1及MMP-9阳性表达率与年龄、肿瘤直径、是否绝经无关(P>0.05),与FIGO分期、淋巴结转移、分化程度、病理类型和浸润程度有关(P<0.05)。经Spearman统计分析,HMGB1表达及MMP-9表达在子宫内膜癌患者中呈正相关(r=0.558,P=0.021)。结论 HMGB1及MMP-9在子宫内膜癌患者中呈高表达,二者可能参与了子宫内膜癌的发生和发展。子宫内膜癌患者HMGB1及MMP-9阳性表达率与FIGO分期、淋巴结转移、分化程度、病理类型和浸润程度有关,HMGB1表达及MMP-9表达在子宫内膜癌患者中呈正相关。
Objective To investigate the positive expression rate of high mobility group box 1 (HMGB1) and matrix metalloproteinase-9 (MMP-9) in endometrial carcinoma and analyze their correlation. Methods Sixty patients with endometrial cancer from February 2015 to October 2016 were selected as the endometrial cancer group and the cancerous normal tissues were taken as the paracancer group. Another 60 cases of simple endometrial hyperplasia patients who underwent hysterectomy in the same period were selected as the control group. The positive expression rates of HMGB1 and MMP-9 in the three groups were detected and compared. The positive rates of HMGB1 and MMP-9 in patients with endometrial carcinoma were analyzed with age, tumor diameter, menopause, FIGO stage, lymph node metastasis, differentiation, pathological type and Infiltration of the relationship between HMGB1 expression and analysis of the correlation between MMP-9 expression. Results The positive rates of HMGB1 and MMP-9 in the three groups were significantly different (P <0.05). The positive expression rate of HMGB1 in endometrial carcinoma group was significantly higher than that in paracancer group and control group (P <0.05). The positive rate of MMP-9 in endometrial carcinoma group was significantly higher than that in paracancer group and control group (P <0.05). The positive rates of HMGB1 and MMP-9 in endometrial carcinoma were not correlated with age, tumor diameter and menopause (P> 0.05), but also correlated with FIGO stage, lymph node metastasis, differentiation degree, pathological type and infiltration degree (P <0.05). According to Spearman statistical analysis, HMGB1 expression and MMP-9 expression were positively correlated in patients with endometrial carcinoma (r = 0.558, P = 0.021). Conclusion HMGB1 and MMP-9 are highly expressed in patients with endometrial cancer, both of which may be involved in the occurrence and development of endometrial cancer. The positive rates of HMGB1 and MMP-9 in endometrial carcinoma were correlated with FIGO stage, lymph node metastasis, differentiation degree, pathological type and degree of infiltration. The expression of HMGB1 and the expression of MMP-9 in endometrial carcinoma patients were positively correlated.