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目的探讨八珍汤对乳腺癌患者血管生成的抑制作用及机制。方法将90例乳腺癌患者分为3组,组术前给予化疗,组术前给予化疗和八珍汤,组术前不干预处理。观察患者的近期疗效情况,检测治疗前后血清血管内皮细胞生长因子(s-VEGF)、治疗后肿瘤微血管密度(MVD)、肿瘤VEGF蛋白。结果与组比较,组和组均可显著提高近期总有效率(P<0.05),降低进展率(P<0.01);组治疗后s-VEGF较治疗前有显著降低(P<0.05),并且低于组(P<0.05);干预前所有患者s-VEGF浓度与肿瘤大小、淋巴转移、TNM分期呈正相关;组MVD和肿瘤血管内皮细胞生长因子(VEGF)蛋白较组均有显著降低(P<0.05);干预后s-VEGF与癌组织VEGF、MVD存在正相关关系。结论八珍汤可抑制乳腺癌血管生成,其机制可能与抑制肿瘤组织中VEGF的表达有关。
Objective To investigate the inhibitory effect of Bazhen decoction on angiogenesis in breast cancer patients and its mechanism. Methods Ninety patients with breast cancer were divided into three groups. The patients were given chemotherapy before operation. The patients were given chemotherapy and Bazhen Decoction before operation. The patients were treated with no preoperative intervention. The curative effect of the patients was observed. The levels of serum vascular endothelial growth factor (s-VEGF), tumor microvessel density (MVD) and VEGF protein in the tumor before and after treatment were measured. Results Compared with the control group, the total effective rate (P <0.05) and the rate of progress (P <0.01) of both groups and groups were significantly improved. The s-VEGF levels of the two groups were significantly lower than those before treatment (P <0.05) (P <0.05). The levels of s-VEGF in all patients before intervention were positively correlated with tumor size, lymphatic metastasis and TNM stage. The levels of VEGF and MVD in tumor tissues were significantly decreased <0.05). There was a positive correlation between s-VEGF and VEGF, MVD in cancer tissue after intervention. Conclusion Bazhen Decoction can inhibit the angiogenesis of breast cancer, the mechanism may be related to the inhibition of VEGF expression in tumor tissue.