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目的:考察注射用参附回阳救逆,益气固脱及对胸痹证等的治疗作用。方法:研究了注射用参附对小鼠内毒素性休克死亡的作用,对失血性休克猫的影响,对麻醉开胸犬心肌缺血—再灌注损伤的影响。结果:注射用参附静脉注射给药对小鼠内毒素性休克死亡有明显的保护作用,其ED50为21.8mg/kg,与阳性组比较结果无显著性差别(P>0.05);对失血性休克猫呼吸、血压、房室间,室间传导阻滞程度有明显的改善作用,缓解心肌缺血,对失血性休克猫存活时间及存活率均有明显的增加,存活率与对照组比较差别有极显著意义(P<0.01);对麻醉开胸犬心肌缺血—再灌注的影响主要对缺血—再灌注损伤的心肌细胞有很好的保护作用,减少心肌梗死范围。注射用参附中剂量在后二个实验中各项指标与阳性对照组相比差别无显著意义(P>0.05)。结论:注射用参附具有回阳救逆,益气固脱及治疗胸痹的药理作用,与阳性对照参附注射液相比作用基本一致。
OBJECTIVE: To investigate the therapeutic effect of Shenfu injection for invigorating the body, invigorating the Qi, removing off the Qi and treating the chest plexus. Methods: The effect of Shenfu injection on the death of endotoxic shock in mice and the effect on hemorrhagic shock cats and the myocardial ischemia-reperfusion injury in anesthetized open-chest dogs were studied. Results: The injection of Shenfu injection had obvious protective effect on the death of endotoxic shock in mice. The ED50 was 21.8mg / kg, which showed no significant difference compared with the positive group (P> 0.05) Shock, cats breathing, blood pressure, atrioventricular and ventricular conduction block were significantly improved to relieve myocardial ischemia, hemorrhagic shock cat survival time and survival rates were significantly increased, the survival rate compared with the control group difference (P <0.01). The effect of myocardial ischemia-reperfusion on the thoracotomy dogs was mainly for the protection of myocardial cells with ischemia-reperfusion injury and the extent of myocardial infarction. There was no significant difference in the indexes of Shen-Zhong Zhong for middle and late dose injection (P <0.05) compared with the positive control group. Conclusion: Shenfu injection has the pharmacological action of Yang-Yang-Qi, Qi-Qi and Xie-Fu-Injection, which are basically the same as the positive control Shenfu Injection.