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目的:观察氯沙坦治疗原发性高血压并高尿酸血症的降压和降尿酸作用。方法:120例高血压并高尿酸血症患者随机分为治疗组与对照组,观察给药前后血压和血尿酸变化。结果:用药8周后2组患者收缩压和舒张压与治疗前比较差异有统计学意义(P<0.01),2组间降压疗效比较差异无统计学意义(P>0.05);治疗组用药8周后与用药前比较血尿酸浓度差异明显(P<0.01),而对照组用药8周后与用药前比较血尿酸浓度差异无统计学意义(P>0.05)。结论:氯沙坦可降低高血压合并高尿酸血症患者血压和血清尿酸水平,合并高尿酸血症的高血压病人可安全选用氯沙坦。
Objective: To observe the antihypertensive and uricosuric effects of losartan in the treatment of essential hypertension and hyperuricemia. Methods: One hundred and twenty patients with hypertension and hyperuricemia were randomly divided into treatment group and control group. The changes of blood pressure and serum uric acid before and after administration were observed. Results: After 8 weeks of treatment, the systolic and diastolic blood pressures in two groups were significantly different from those before treatment (P <0.01). There was no significant difference in antihypertensive effect between the two groups (P> 0.05) After 8 weeks, the concentration of serum uric acid was significantly different from that before treatment (P <0.01), while there was no significant difference in the concentration of serum uric acid between the 8-week and 8-week after treatment (P> 0.05). CONCLUSION: Losartan can reduce blood pressure and serum uric acid in patients with hypertension and hyperuricemia. Losartan can be safely used in hypertensive patients with hyperuricemia.