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目的探讨β受体阻滞剂美托洛尔在慢性充血性心力衰竭(CHF)中的应用。方法比较CHF在内科常规治疗基础上加用美托洛尔治疗4周及8周后,比较患者治疗前后的临床指标变化。评估其临床疗效及安全性。结果治疗4~8周后心率、血压均较治疗前明显降低(P<0.05或0.01)。4周后心功能改善总有效率为60.00%,8周后为81.67%,两者比较P<0.05。结论在常规抗心力衰竭药物治疗基础上加用小剂量美托洛尔可明显改善心功能。
Objective To investigate the application of β-blocker metoprolol in chronic congestive heart failure (CHF). Methods The changes of clinical indexes of CHF patients before and after treatment were compared between 4 weeks and 8 weeks after metoprolol plus metoprolol treatment. To assess its clinical efficacy and safety. Results After 4 to 8 weeks of treatment, heart rate and blood pressure were significantly lower than those before treatment (P <0.05 or 0.01). After 4 weeks, the total effective rate of heart function improvement was 60.00% and 81.67% after 8 weeks, both P <0.05. Conclusion Addition of metoprolol in low dose on the basis of conventional anti-heart failure drug therapy can significantly improve cardiac function.